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Abteilung Biobank Graz OE für Forschungsinfrastruktur OEs Med Uni Graz

Für Forscher*innen

Die Biobank Graz ist eine zentrale Serviceeinrichtung der Medizinischen Universität Graz und unterstützt die biomedizinische Forschung durch das Sammeln, Bearbeiten und Lagern von hochqualitativen biologischen Proben und den zugehörigen Daten. Die Biobank Graz arbeitet eng mit akademischen und industriellen Forschungspartner*innen zusammen, indem sowohl gezielt Kohorten aufgebaut als auch Basissammlungen betrieben und die Proben mit den dazugehörigen anonymisierten/pseudonymisierten Daten für Forschungsprojekte zur Verfügung gestellt werden.

Probensammlungen

Die Biobank Graz an der Medizinischen Universität Graz unterstützt Biobanking-Projekte am Universitätsklinikum Graz. Zusätzlich werden in der Biobank Gewebeproben (FFPE-Blöcke und -Schnitte) des Diagnostik- & Forschungsinstituts für Pathologie gelagert. Für einen besseren Überblick hat das Team der Biobank Graz laufende und auch bereits abgeschlossene Probensammlungen nach ihrer fachlichen Zuordnung untenstehend zusammengefasst.

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Projektmanagementteam

T: +43 316 385 72716

E: biobank-pm(at)medunigraz.at

Kennzahlen 2023

Kohortenprofile

COVID-19 Kohorten

COVAC-DM Study

Keywords: diabetes mellitus type 1, diabetes mellitus type 2, COVID-19, COVID-19 vaccine
Sample types: serum, EDTA-plasma, sodium citrate plasma, saliva
Project leader: Harald Sourij
Information

COVID-19 Convalescent Cohort

Keywords: COVID-19 recovered patients, SARS-Cov-2, PCR test, antibody test
Sample types: serum, EDTA-plasma, buffy coat, lithium heparin plasma, sodium citrate plasma, nasopharyngeal swab, saliva
Project leaders: Robert Krause; Christian Gülly; Peter Schlenke; Ivo Steinmetz; Markus Herrmann
Information

HBO Post-Covid

Keywords: ongoing Covid-19, long Covid-19, hyperbaric oxygen
Sample types: Serum
Project leader: Freyja-Maria Smolle-Jüttner
Information

The CoVVac Study

Keywords: COVID-19 vaccination, immunocompromised, t-cell immunity, t-cell aging,
Sample types: serum, saliva, PBMC´s
Project leader: Martin Stradner
Information

The CoVVacBoost Study

Keywords: vaccination, COVID-19, SARS-CoV-2, mRNA vaccine, booster, 3^rd dose, Moderna, Comirnaty, AstraZeneca
Sample types: serum, saliva, PBMC´s
Project leaders: Martin Stradner; Ivo Steinmetz
Information

Dermatologie und Venerologie

Bio-UV 2017

Keywords: photo(chemo)therapy, skin diseases, molecular mechanisms
Sample types: serum, EDTA-plasma, buffy coat, PAXgene, cells
Project leader: Peter Wolf
Information

Photo-responsive Diseases

Keywords: UV therapy, therapeutic response, biomarkers, inflammatory skin diseases, cutaneous T-cell, lymphoma (CTCL), vitiligo, graft-versus-host disease (GvHD), mast cell diseases
Sample types: serum, whole blood
Project leader: Peter Wolf
Information

Psoriasis

Keywords: psoriasis
Sample types: serum, EDTA-plasma, buffy coat, PAXgene
Project leader: Peter Wolf
Information

Endokrinologie

BioPersMed

Keywords: biomarker, metabolism, cardiology, diabetes, osteoporosis, fatty liver disease, cardiovascular diseases, endocrinology
Sample types: serum, EDTA-plasma, buffy coat, lithium heparin plasma, sodium citrate plasma, urine
Project leaders: Barbara Obermayer-Pietsch; Nicolas Verheyen
Information
Article
Samples

Diabetes Registry

Keywords: diabetes, lipid metabolism, obesity, endocrinology
Sample types: serum, EDTA-plasma, buffy coat, urine
Project leaders: Harald Sourij; Caren Sourij
Information
Article

EMMY

Keywords: myocardial infarction, empagliflozin, RCT, placebo, SGLT-2 inhibitor, heart failure
Sample types: serum, EDTA-plasma, whole blood, sodium citrate plasma, urine
Project leaders: Harald Sourij; Norbert Tripolt
Information
Article

Interfast

Keywords: alternate day fasting, intermittent fasting, healthy subjects, RCT
Sample types: serum, EDTA-plasma, urine
Project leaders: Harald Sourij; Thomas Pieber
Information
Article
Samples

PoCOsteo

Keywords: osteoporosis, osteoporotic fracture, metabolic bone disease
Sample types: serum, EDTA-plasma, buffy coat
Project leader: Hans Peter Dimai
Information
Article

STEMI-Lipids

Keywords: stemi, myocardial infarction, lipids
Sample types: serum, EDTA-plasma, buffy coat
Project leader:Harald Sourij
Information
Article

ProPCO-RCT

Keywords: Polycystic Ovary Syndrome, PCOS, probiotics, metformin, RCT, randomized controlled trial, testosterone
Sample types: Serum, EDTA-plasma, EDTA-buffy coat, urine
Project leader: Barbara Obermayer-Pietsch
Information

Vitamin D Hypertension Cohort

Keywords: Vitamin D, hypertension, cardiovascular risk factors
Sample types: serum, EDTA-plasma, urine
Project leader: Stefan Pilz
Information

Gesunde Kontrollgruppe

Blood Bank Collection

Keywords: blood bank, healthy subjects
Sample types: serum, EDTA-plasma, buffy coat
Project leader: Peter Schlenke
Information

Gynäkologie und Geburtshilfe

Gestational Diabetes Mellitus Cohort

Keywords: pregnancy, diabetes mellitus (DM), gestational diabetes (GDM)
Sample types: serum, EDTA-plasma, buffy coat
Project leader: Mila Cervar-Zivkovic
Information

Gynaecological Tumours

Keywords: gynaecological cancers, blood, cryopreserved tissue
Sample types: plasma, buffy coat, whole blood, fresh frozen tissue
Project leaders: Karl Tamussino; Mila Cervar-Zivkovic: Peter Regitnig
Information

Placenta & Cord Blood Collection

Keywords: placenta, umbilical cord blood, biomarkers, pregnancy disorders
Sample types: serum, plasma, buffy coat, fresh frozen placental tissue
Project leader: Mila Cervar-Zivkovic
Information

Pregnancy Hypertension Cohort

Keywords: gestational hypertension, blood samples
Sample types: serum, EDTA-plasma, buffy coat
Project leader: Mila Cervar-Zivkovic
Information

Hämatologie

Myeloid Neoplasias Collection

Keywords: myeloid neoplasias (MN), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), myeloproliferative neoplasias (MPN)
Sample types: buffy coat, mononuclear cells
Project leader: Armin Zebisch
Information

Innere Medizin

Clinibil Study

Keywords: fluid and electrolyte balance, post cardiac-surgery, AKI biomarkers
Sample types: serum, urine
Project leader: Philipp Eller
Information

Kardiologie

ROC-HF

Keywords: chronic heart failure, bone metabolism, osteoporosis, hemodynamic
Sample types: serum, EDTA-plasma, buffy coat, urine
Project leaders: Nicolas Verheyen; Klemens Ablasser
Information

HCM Register

Keywords: hypertrophic cardiomyopathy, HCM, biomarkers, cardiac amyloidosis
Sample types: serum, EDTA-plasma, buffy coat, Na-Citrate plasma,urine
Project leaders: Nicolas Verheyen; Klemens Ablasser
Information

Nephrologie

Kidney Transplant Cohort

Keywords: kidney, transplantation, renal insufficiency
Sample types: Serum, EDTA plasma, buffy coat
Project leader: Eller Kathrin
Information

Neurologie und Neurochirurgie

MRT Brain Cohort

Keywords: MRT, brain sections, lesions
Sample types: snap frozen tissue
Project leaders: Reinhold Schmidt; Johannes Haybäck
Information

Neurosurgery Collection

Keywords: brain tumors, intervertebral discs, epilepsy
Sample types: serum, EDTA-plasma, buffy coat, snap frozen tissue
Project leader: Stefan Wolfsberger
Information

Neurology Collection

Keywords: neurodegeneration, neuroinflammation, controls, lumbar puncture, cerebrospinal fluid, serum, biomarkers
Sample types: serum, cerebrospinal fluid, CSF cells
Project leaders: Michael Khalil
Information

Onkologie

Oncology Collection

Keywords: body fluids, cancer patients, solid tumors
Sample types: serum, EDTA-plasma, buffy coat, whole blood
Project leader: Philipp Jost
Information

Radiotherapy Collection

Keywords: biomarker, cancer, radtiotherapy
Sample types: serum, EDTA-plasma, buffy coat
Project leader: Thomas Baptist Brunner
Information

Testicular Cancer Cohort

Keywords: Testicular cancer, stage I, diagnostic tumor markers
Sample type: serum
Project leader: Martin Pichler
Information

Early detection of CRC

Keywords: CRC, colorectal cancer, tissue, early detection
Sample type: serum, EDTA-plasma, buffy coat, snap frozen tissue
Project leader: Felix Aigner, Robert Sucher, Philipp Stiegler
Information

Orthopädie

Orthopaedics Collection

Keywords: Arthrosis – coxarthrosis – gonarthrosis - bone sarcoma - bone tumour - soft tissue tumour - soft tissue sarcoma
Sample types: serum, EDTA-plasma, buffy coat, whole blood, snap frozen tissue
Project leader: Andreas Leithner
Information

Kinder- und Jugendheilkunde und Kinder- und Jugendchirurgie

PERFORM

Keywords: infection, febrile illness in childhood
Sample types: EDTA-plasma, whole blood, urine, stool, liquor, PAXgene
Project leader: Werner Zenz
Information
Article

CONGENITAL EXTRACRANIAL VASCULAR ANOMALIES

Keywords: vascular malformation, venous malformation, lymphatic malformation, ateriovenous malformation
Sample types: EDTA-plasma, buffy coat, snap frozen tissue
Project leader: Christina Flucher
Information

Pathologie

FFPE Slides Collection

Keywords: FFPE slides, histopathological reports, survival data, digital images
Sample types: FFPE Slides
Porject leader: Kurt Zatloukal; Gerald Höfler
Information

Colorectal Cancer Whole Slide Image - Clinical Annotation Cohort

Keywords: CRC, colorectal cancer, AI, artificial intelligence
Sample types: Whole slide images, FFPE Slides
Project leader: Kurt Zatloukal
Information

Colorectal Cancer Whole Slide Image - Survival Cohort

Keywords: CRC, colorectal cancer, survival, AI, artificial intelligence
Sample types: Whole slide images, FFPE Slides
Project leader: Kurt Zatloukal
Information

Colorectal Cancer Whole Slide Image - Vascular Invasion Cohort

Keywords: CRC, colorectal cancer, inflammation, AI, artificial intelligence
Sample types: Whole slide images, FFPE Slides
Project leader: Kurt Zatloukal
Information

Psychiatrie und Psychotherapeutische Medizin

Blood and Tears

Keywords: blood collection, affective disorders, schizophrenic disorders, anxiety, metabolomics, genetics, machine-based learning
Sample types: serum, EDTA-plasma, buffy coat
Project leader: Eva Reininghaus
Information

Pulmonologie

LBI LVR Pulmonary Vascular Collection

Keywords: pulmonary cells, blood, tissue, PH
Sample types: serum, whole blood, lithium heparin plasma, snap frozen tissue, cells
Project leader: Grazyna Kwapiszewska-Marsh
Information

Reproduktionsmedizin

CReATe Biobank Canada

Keywords: fertility, reproductive research, IVF
Sample types: somatic cells, follicular fluid, eggs, abnormal embryos, embryo fluid, uterine fluid or cells, semen samples, culture media
Website
Article

KIWI Collection

Keywords: fertility, reproductive medicine, IVF, follicular fluid, cumulus cells
Sample types: serum, follicular fluid, cumulus cells, embyo culture supernatant, seminal plasma
Project leader: Michael Schenk
Information
Article
Samples

Thoraxchirurgie und Hyperbare Chirurgie

Vitamin D3 in Thoracic Surgery Cohort

Keywords: Vitamin D deficiency, thoracic surgery, cancer patients
Sample types: serum, EDTA-plasma, buffy coat, snap frozen tissue
Project leader: Jörg Lindenmann
Information

Thorax IL-6 Sepsis Marker Cohort

Keywords: IL-6, biomarker, SIRS, sepsis
Sample types: whole blood, lithium heparin plasma
Project leader: Freyja-Maria Smolle-Jüttner
Information

Zelllinien der Med Uni Graz

In vitro Experimente in unterschiedlichen Zellsystemen können Tierversuche reduzieren und ersetzen. In jedem Fall bilden in vitro Versuche die Grundlage für Tierversuche im Sinne des 3R Prinzips. Die CellBank Graz stellt Forschenden humane und tierische Zelllinien zur Verfügung, die einem hohen Qualitätsstandard entsprechen.

Zelllinien werden auch auf Bedarf etabliert und eingehend charakterisiert.

Nicht-tumorigene Zelllinien:

humane, juvenile Fibroblasten
humane, adulte, dermale Fibroblasten
humane, juvenile Keratinozyten
MUG Lucifer iHDF, immortalisierte humane, dermale Fibroblasten
humane, juvenile Melanozyten
humane, adulte, dermale Melanozyten

Chordom Zelllinien:

MUG-Chor1: Humanes sakrales Chordom
MUG CC1: Humanes clivales Chordom

Melanom Zelllinien:

MUG Mel 2: humanes NRAS mutiertes Melanom
MUG Mel 3: humanes BRAF Melanom einer schwangeren Patientin

Sarkom Zelllinien:

MUG CiDus: humanes Cix Dux 4 Sarkom
MUG Lucifer: humanes Klarzellsarkom
MUG Lucifer Metastase: humanes Klarzellsarkom Lungenmetastase
MUG Myx2: humanes Myxofibrosarkom

Cholangio-Karzinom Zelllinien:

MUG CCArly 1: humanes Cholangiokarzinom/Klatskintumor

Kontakt: Beate Rinner